Each m-Torquer is engineered to generate sufficient torque (F𝜏) within a magnetic field to gate mechanosensitive ion channels. Our system employs a rotational magnetic force generator (MFG), which applies a rotating magnetic field that enables the m-Torquer to exert mechanical torque. Under magnetic fields of 20–50 mT, the m-Torquer produces forces of 2–10 pN, effective at working distances of tens of centimeters.

 

The m-Torquer is constructed by assembling a monolayer of octahedral nanoparticles onto a spherical support via click chemistry. Its design allows extensive customization, including adjustments to overall size, magnetic properties, fluorescent labeling, and targeting moieties to fit specific research needs.