Magnetogenetics Toolbox
This page highlights the core components of our Magnetogenetics Toolbox, showcasing the technologies that make non-invasive, wireless, and cell-type-specific neuromodulation possible. From engineered magnetic nanoparticles and precision instrumentation to mechanosensitive ion channels and customizable genetic systems, each feature contributes to advancing neuroscience research with accuracy, versatility, and reproducibility. Together, these capabilities form a powerful platform for exploring and controlling neural activity in freely moving animals.
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Small size (150 – 500 nm)
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Biocompatible & non-toxic: silica coated, PEGylated
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0.1 – 50 pN force generation (adequate for most mechanosensitive receptors)
Magnetic nanoparticles
(m-Torquer)
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Versatile platform for diverse mechanosensitive ion channels & receptors
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Ion channels: (for excitation) Piezo1/2, TRP family, (for inhibition) FLYC1
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Receptors: T cell receptor, Notch (synNotch), integrin
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Delivery: viral (AAV, Lenti, AV), non-viral (LNP)
Mechanosensitive
proteins
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Long working distance (~1 meter: similar to MRI bore size)
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Scalable: 16-, 35-, and 70-cm diameter à larger setup is possible
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Stimulation frequency: up to 10 Hz (permanent magnet), ~30 Hz (electromagnet)
MG instrumentation
(Magnetic Force
Generator, MFG)
Magnetogenetics System Overview
